Tag Archives: phd

CASE PhD studentship in Bioinformatics available at Newcastle

A repost from Fuzzier Logic:

Where? – Newcastle University – School of Computing Science

What? – Development of Novel Computational Approaches to Mine Integrated Datasets for Drug Repurposing Opportunities

The blurb

We invite applications for a CASE PhD studentship in Bioinformatics at Newcastle University in the North East of England. The project is a 3-year EPSRC PhD sponsored by GlaxoSmithKline (GSK) and involves the development of novel methods of finding new targets for existing drugs using data integration.

Ondex is a data integration computational platform for Systems Biology (SB). The student will research the optimization and application of Ondex integrated datasets to the identification of repurposing opportunities for existing compounds with a particular, but not exclusive, focus in the infectious diseases therapeutic area. The student will also use the dataset to explore the interplay between microbial targets and perturbations in the metabolic and community structure of the human gut microbiome.

An ideal student will have a background in computing science, good programming skills, preferably in Java and an interest in biology and bioinformatics. Applicants should also possess an upper second class undergraduate degree. Only students who meet the EPSRC home student requirements are eligible for full fees, other EU students are only eligible to support for the fees. Students from outside the EU are not eligible to apply – please see the EPSRC website for details.

The studentship will start in October 2011, jointly supervised by Prof. Anil Wipat and Dr. Simon Cockell at Newcastle University, and Dr. Philippe Sanseau at GSK. The student will spend at least three months at GSK in Stevenage as part of the project. Home students are eligible for payment of full fees and an enhanced stipend of approximately £18,000 tax free. To apply, please send an email to [anil dot wipat at ncl dot ac dot uk] with CV (including the contact details of least two referees) and a cover letter indicating your suitability for the position. Please include “Application CASE PhD” in the subject of the email. Applications will be dealt with as they arrive – there is no closing date.

PhD position available at Newcastle

Reposted from Philip Lord’s blog ‘An Exercise in Irrelevance

PhD Studentship, 2010

EPSRC PhD Studentship Building a logical model of biology: the Ontology of Mitochondria

For this project, you will use cutting edge technology designed for the Semantic Web, and apply it to the new field of systems biology. Specifically, you will develop an OWL ontology, a formal, logically specified model, to describe the mitochondria, a subsystem of the cell. You will use this to integrate large amounts of real-world data, to search for inconsistencies and produce a predictions about the underlying biology. From a computing perspective, this will result in insights both about the technology, and its scalablity; from a systems biology perspective, you gain understanding of the value of models which are wider than traditional mathematical models; from a biomedical perspective, you may gain insight in the functioning and behaviour of a medically important system of the cell.

This is a challenging multi-disciplinary project; applicants are not expected to understand all its aspects at the outset; as a result, it is of interest to those from either a computing science, computational biology or bioinformatics background. Any experience of ontologies, modelling or mitochondrial biology will be an advantage, but is not required. A willingness to learn is critical; students will spend significant time in both a computing science and biology environment, and will become familiar with both.

You should have either a First or 2.1 in Computing Science, a Biological Science or Mathematics, and a distinction level Masters degree in a related subject. Equivalent experience will also be considered.

Depending on how you meet the EPSRC’s eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,290 (2009/10). A partial award covers fees at the UK/EU rate only.

For further details, please contact Phillip Lord